李美慧教授

李美慧 教授

辦公室 : 地理系館603室

Email : Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它

電話 : 886-2-33665839

網站 : 環境生態實驗室

 

本人教學與研究興趣橫跨不同的研究領域，包括環境毒理、醫學地理學與環境生態。近期研究在國科會補助下，主要在探討內分泌干擾物質對水生生物的影響；另外也探討都市化對環境生態之影響等相關研究工作。如此多元的研究興趣實乃反映我個人的訓練背景，包括來至地理學的學士學位、動物學的碩士學位，以及環境毒理的博士學位。

研究專長 : 環境毒理及生物監測、都市化對環境生態影響、河川生態系健康

 

學歷

年份	學位
1996	美國伊利諾大學香檳分校環境毒理學博士
1991	美國南伊利諾大學動物學碩士
1987	國立台灣大學地理系學士

經歷

起迄年份	服務機構	部門	職稱
2009-Present	國立台灣大學	地理環境資源學系	教授

1. 持久性有機污染物與環境污染問題

我對於持久性有機污染物的毒性作用十分感興趣，曾進行的研究包括：多氯聯苯對肝臟酵素的誘導與內分泌系統之影響；聚溴聯苯醚對肝臟酵素的誘導與生殖之影響；壬基苯酚對水中生物的毒性作用與全氟辛酸 (銨) 對水中生物的毒性作用；新興污染物的水生生態毒性。

2. 生物監測於環境監測之應用

我對使用生物監測法對台灣環境品質進行監測亦有極大的興趣。一些主要的研究包括：從螃蟹發育之不穩定性監測海岸污染程度；植物的抗氧化酵素誘發對空氣污染的監測；雄性魚卵黃蛋白的誘發作用與內分泌干擾物質暴露等相關研究。

3. 環境生態議題

我對人類活動或人為干擾對生物的生存及分布的影響之相關環境生態議題也相當關切，特別是都市化對不同生物的生存及分布的影響；不同土地利用對生物多樣性的影響等。

4. 人體健康與環境

我對研究人體健康與全球環境變遷也有高度興趣，特別是關於持續性有機物污染對健康的影響。此外，醫學地理學中關於氣候變遷與人體健康、流行性傳染病與新興流行傳染病，以及疾病的地理分布等也都在我的研究範圍之內。

 

2011 ~ 2015 教授課程：

環境生態學及實習             Environmental Ecology and Lab

環境毒理                        Environmental Toxicology

生態監測簡介                  Introduction to Ecological Monitoring

環境變遷中生態議題          Ecological Issues in a Changing World

 

氣候變遷議題實作（二）    Workshop on Climate Change (II)

(林博雄與吳金鏞合開。與李美慧、簡旭伸、陳正平、羅敏輝、許瑛玿、張聖琳合開)

專題討論一                     Seminar (Ⅰ)

學士論文上下                  Thesis (b.s.) (1) (2)

 

Refereed Articles (2001年迄今):

Li, M.-H. (2016) Development of in vivo metabolic enzyme assays for ecotoxicity screening: In vivo measurement of phases I and II enzyme activities in freshwater planarians. Ecotoxicology and Environmental Safety 130:19-28.

Wu, J.-P. and  Li, M.-H.* (2015) Inhibitory effects of pain relief drugs on neurological enzymes: implications on their potential neurotoxicity to aquatic animals. Environmental Toxicology and Pharmacology 39:898-905. (SCI)

Wu, J.-P., Li, M.-H. Chen, J.-S., and Lee, H.-L. (2015) Disturbances to neurotransmitter levels and their metabolic enzyme activity in a freshwater planarian exposed to cadmium. Neurotoxicology 47:72-81.(SCI)

Li, M.-H. (2014) Effects of bisphenol A, two synthetic and a natural estrogens on head regeneration of the freshwater planarians, Dugesia japonica. Toxicological and Environmental Chemistry96: 1174-1184. (SCI).

Wu, J.-P., Lee, H.-L, and Li, M.-H.* (2014) Cadmium neurotoxicity on a freshwater planarian. Archives of Environmental Contamination and Toxicology 67:639-650. (SCI)

李美慧 (2013)都市化河川水質時空變化-以基隆河為例。環境與世界 27: 77-96.

 Li, M.-H. (2013) Acute toxicity of thirty pharmaceutically active compounds to freshwater planarians, Dugesia japonica. Toxicological and Environmental Chemistry 95(7): 1157-1170. (SCI)

Li, M.-H. (2013) Acute toxicity of industrial endocrine-disrupting chemicals, natural and synthetic sex hormones to the freshwater planarians, Dugesia japonica. Toxicological and Environmental Chemistry 95(6): 984-991. (SCI)

Tseng, L.-H., Hsu, P.-C., Lee, C.-W., Tsai, S.-S., Pan, M.-H., and Li, M.-H. (2013) Developmental exposure to decabrominated diphenyl ether (BDE-209): effects on sperm oxidative stress and chromatin DNA damage in mouse offspring. Environmental Toxicology 28: 380-389. (SCI)

Lee,T.-H. and Li, M.-H.* (2013) Intertidal assemblages on artificial structures and natural rocky habitats on Taiwan’s north coast. Raffles Bulletin of Zoology 61: 331-342. (SCI)

Wu, J.-P., Chen, H.-C., and Li, M-H.*(2012) Bioaccumulation and toxicodynamics of cadmium in the freshwater planarian and the protective effects of N-acetylcysteine. Archives of Environmental Contamination and Toxicology 63: 220-229. (SCI)

Wu, J.-P., Li, M.-H. Chen, J.-S., and Lee, H.-L. (2012) In vivo and in vitro metabolism of tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by freshwater planarian, Dugesia japonica. Chemosphere 87:1341-1347. (SCI)

Li, M.-H.(2012) Survival, mobility, and membrane-bound enzyme activities of freshwater planarians, Dugesia japonica, exposed to synthetic and natural surfactants. Environmental Toxicology and Chemistry 31(4):843-850. (SCI)

Li, M.-H. (2012) Acute toxicity of benzophenone-type UV filters and paraben preservatives to freshwater planarians, Dugesia japonica. Toxicological and Environmental Chemistry 94(3):566-573. (SCI)

李宗翰、李美慧*(2012)遊客踩踏行為對岩岸潮間帶附著生物的影響。戶外遊憩研究 25(1):1-24. (TSSCI)

Wu, J.-P., Chen, H.-C., Li, M.-H.* (2011) The preferential accumulation of cadmium in the head portion of the freshwater planarian, Dugesia japonica (Platyhelminthes: Turbellaria). Metallomics 3:1368-1375. (SCI)

Li, M.-H.(2011) Changes of cholinesterase and carboxylesterase activities in male guppies (Poecilia reticulate), after exposure to ammonium perfluorooctanoate, but not perfluorooctane sulfonate.Fresenius Environmental Bulletin 20: 2065-2070. (SCI) 

Li, M,-H., 2010. Chronic effects of perfluorooctane sulfonate and ammonium perfluorooctanoate on biochemical parameters, survival and reproduction of Daphnia magna, Journal of Health Science, 56, 104-111. (SCI)

Lin, C.-W; Li, M,-H., 2009. Effects of two types of landfills on river water quality and endocrine disruptor concentrations before and after rainfall in a subtropical climate, Water Quality Research Journal of Canada, 44, 355-363. (SCI)

Li, M.-H., 2009. An overview of environmental health status and related studies in Taiwan, Bulletin of the Geographical Society of China, 42,1-24.

Li, M.-H., 2009. Toxicity of perfluorooctane sulfonate and perfluorooctanoic acid to plants and aquatic invertebrates, Environmental Toxicology, 24, 95-101. (SCI)

Li, M.-H., 2008. Effects of nonylphenol on cholinesterase and carboxylesterase activities in male guppies (Poecilia reticulata), Ecotoxicology and Environmental Safety, 71, 781-786. (SCI)

Li, M.-H. (2008) Effects of nonionic and ionic surfactants on survival, oxidative stress, and cholinesterase activity of planarian. Chemosphere 70:1796-1803. (SCI)

Tseng, L.-H.; Li, M.-H.; Tsai, S.-S.; Lee, C.W.; Pan, M.-H.; Yao, W.-J.; Hsu, P.-C., 2008. Developmental exposure to decabromodiphenyl ether (PBDE 209): effects on thyroid hormone and hepatic enzyme activity in male mouse offspring, Chemosphere, 70, 640-647. (SCI)

Hong, L.; Li, M.-H., 2007. Acute toxicity of nonylphenol to aquatic invertebrates in Taiwan. Bulletin of Environmental Contamination & Toxicology, 78, 445-449. (SCI)

Tseng, L.-H.; Lee, C.W.; Pan, M.-H.; Tsai, S.-S.; Li, M.-H.; Chen, J.-R.; Lay, J.-J.; Hsu, P.-C., 2006. Postnatal exposure of the male mouse to 2,2',3,3',4,4',5,5',6,6'- decabrominated diphenyl ether: decreased epididymal sperm functions without alterations in DNA content and histology in testis, Toxicology, 224, 33-43. (SCI)

李美慧，2005。 醫學地理的熱門課題--「新興傳染病」的研究，地理學報， 41，45-64。 (TSSCI)

Li, M.-H.; Wang, Z.-R., 2005. Effect of nonylphenol on plasma vitellogenin of male adult guppies (Poecilia reticulata), Environmental Toxicology, 20, 53-59. (SCI)

王振叡、李美慧，2004。 外因性內分泌干擾物對魚類生殖的影響。生物科學 ，47(1)，19-34。

Li, M.-H., 2004. Morphological biomarkers of shore crabs (Grapsus albolineatus) living in the vicinity of a coastal landfill site. Fresenius Environmental Bulletin, 13, 485-490. (SCI)

Hsu, P.-C.; Guo, Y.L.; Li, M.-H., 2004. Effects of postnatal exposure to 3,3’,4,4’- tetrachlorobiphenyl on sperm function and hormone levels in adult rats, Chemosphere, 54, 611-618. (SCI)

Li, M.-H., 2003. Peroxidase and superoxide dismutase activities in fig leaves in response to ambient air pollution in a subtropical city. Archives of Environmental Contamination & Toxicology, 45, 168-176. (SCI)

Hsu, P.-C.; Li, M.-H.; Guo, Y.L., 2003. Postnatal exposure of 2,2’,3,3’,4,6’- hexachlorobiphenyl and 2,2’,3,4’,5’,6-hexachlorobiphenyl on sperm function and hormone levels in adult rats, Toxicology, 187, 117-126. (SCI)

Li, M.-H., 2002. Potential effects of endocrine disruptors on human health, Taiwan Journal of Public Health, 21, 305-320. (TSSCI) (in Chinese with English Abstract)

Li, M.-H., 2002. Fluctuating asymmetry and intersexuality in the shore crab Grapsus albolineatus near a coastal landfill site in northern Taiwan. Bulletin of Marine Science, 70, 75-88. (SCI)

Rose, R. L.; Khan, M.A.; Li, M.-H.; Gillette, J.S.; Hansen, L.G., 2002. Endocrine effects of episodic polychlorinated biphenyl (PCB) congeners, Review of Toxicology, 4, 161-178.

Li, M.-H., 2001. Shell disease and fluctuating asymmetry in shore crabs near a landfill at the coastal area of Keelung in Taiwan, Fresenius Environmental Bulletin, 10, 576-580. (SCI)

Li, M.-H.; Hsu, P.-C.; Guo, Y.L., 2001. Hepatic enzyme induction and acute endocrine effects of 2,2’,3,3’,4,6’-hexachlorobiphenyl and 2,2’,3,4’,5’,6 -hexachlorobiphenyl in prepubertal female rats, Archives of Environmental Contamination & Toxicology, 41, 381-385. (SCI)

 

Books & Book Chapters :

Wen, T.-H., Lin, M.-H., and Li, M.-H.* (2016) Potential effects of climate changes on dengue transmission- Review of empirical evidences from Taiwan. Rais Akhtar (ed) Climate Change and Human Health Scenario in South and Southeast Asia. pp. 269-281. Springer. (ISBN 978-3-319-23684-1)

Li, M.-H., 2010. Organophosphates. Encyclopedia of Geography. Barney Warf, editor in chief. Sage Publications. (Outstanding Reference Source" award at the American Library Association 2010 midwinter meeting, RUSA 2011 Outstanding Reference Sources Award Winner.)

Li, M.-H., 2010. Herbicide. Encyclopedia of Geography. Barney Warf, editor in chief. Sage Publications. (Outstanding Reference Source" award at the American Library Association 2010 midwinter meeting, RUSA 2011 Outstanding Reference Sources Award Winner.)

李美慧，2006。 生態監測概論，台北：明文書局股份有限公司。

Other:

李美慧，2012。 預防原則、環境荷爾蒙與嬰幼兒健康。科學發展，470，58-63。

李美慧，2009。 全球化的環境污染。科學發展， 440，22-28。

利用淡水渦蟲檢驗水中新興污染物，100.08.01~102.07.31，國科會。

利用渦蟲做為檢測界面活性劑對水生動物毒性之測試系統，97.08.01-100.07.31，國科會。

全氟辛烷磺酸對水生動物之影響II，96.08.01~97.07.31，國科會。

全氟辛烷磺酸對水生動物之影響I，95.08.01~96.07.31，國科會。

利用孔雀魚檢測環境雄性激素，94.08.01~95.07.31，國科會。

 

2012 國立臺灣大學優良期刊論文獎

2010 國立臺灣大學優良期刊論文獎

2009 國立臺灣大學傑出期刊論文獎

2007 國立臺灣大學校教學傑出教師

2006 國立臺灣大學優良期刊論文獎

2004 國立臺灣大學校教學優良教師